![]() To improve the quality of patients’ lives, it is important to gain knowledge about the specific form of the drug and its effect on the safety and efficacy of a therapy as well as the patients’ comfort during application. Both of these factors are closely related to the physicochemical form of the preparation and its rheological and mechanical properties. The causes of these issues should be linked with little effectiveness of the therapy caused by low permeation of the drug into the skin, as well as patients’ disobeying doctors’ recommendations, e.g., concerning regular application of the preparation. The patients complain about skin irritation, clothing stains, unpleasant smell, or excessive viscosity of the preparation. Moreover, many patients with psoriasis are dissatisfied with their current treatment methods and the form with which the drug is applied. The quality of life of patients with psoriasis is decreased because this disease remains incurable, despite the rapid progress of therapeutic methods and the introduction of many innovative antipsoriatic drugs. Psoriasis is a chronic skin disease, and it is especially characterized by the occurrence of red, itchy, and scaly eruptions on the skin. Unfortunately, despite the molecularly targeted treatment, the phenomenon of drug resistance is observed. In the treatment of psoriasis, PUVA photo chemotherapy, UVB irradiation, photo protection, glucocorticosteroids, retinoids, vitamin D analogues, reducing agents, keratotic agents, and immunosuppressant - cyclosporin, methotrexate and hydroxycarbamide as well as biological therapy affecting specific mediators of immune reactions are used. However, one correct treatment regimen cannot be demonstrated, and each therapy should be individually tailored to the patient. In order to assess the severity of psoriatic lesions and choose the appropriate treatment, measuring scales are used, which are mainly based on the physician's visual assessment of psoriatic lesions and the patient's subjective feelings. The choice of method depends on the severity of skin lesions, the frequency of relapses and the course of the disease. Due to, among others, the genetic conditions underlying the disease, complete recovery is not possible, resulting in frequent relapses. ![]() The choice of treatment should enable control of the course of the disease while reducing side effects that may negatively affect the patient's life. The goal of psoriasis treatment is to reduce clinical changes, prolong remission, prevent complications, and restore the patient's life and professional fitness. In the course of psoriasis, increased proliferation of mainly keratinocytes is observed at the tissue level, while increased secretion of proinflammatory cytokines and adipokines is observed molecularly. Precursor factors conditioning the formation of psoriatic lesions may include, among others, strong psychological stress, trauma, acute infection - mainly infections caused by Streptococcus species, surgery, hormonal changes, as well as alcohol abuse, smoking, and taking certain medications. Genetic, behavioral and environmental factors influence the onset, course and severity of skin lesions. Psoriasis is a chronic, inflammatory and recurrent skin disease of an autoimmune nature.
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